This small church was built in the mid-fourteenth century and it seems that it owes its name to the proximity to the Topino river, according to the Foligno historian Ludovico Iacobilli. The original structure was divided into two naves later used for different purposes: one continued to be used as a place of worship, the second as a sacristy, preserving the original Gothic structures.
Inside there are works worthy of note such as a painting of St. John the Evangelist painted by Carlo Botti in 1884 and a wooden statue of St. Apollonia, attributed to Antonio Calcioni.
Outside, on the wall facing via delle Ceneri, there is still an aedicula with a fresco by an unknown artist dating back to the fifteenth century.